| Evapeos sample concentration system for the isolation of thermolabile biomolecules from water
Key Features
- Ideal system for thermo-labile molecules as concentration occurs at temperatures between ambient and 40°C.
- No vacuum required
- Rapid water removal from samples at rates up to 1 L per hour
- Samples up to 1 L can be concentrated
- Wide range of FDA-approved cartridge sizes available for different sample sizes
- Easily interchangeable cartridges can be used for different products in order to avoid
cross-contamination
Current evaporation techniques are often not suitable for thermo-labile
molecules such as proteins because of the high operating temperatures
that are traditionally employed. Discovery is pleased to announce the
introduction of the Evapeos from Ederna of France that promises to
provide a more rapid, low temperature, low pressure solution for the
removal of water from samples containing thermo-sensitive compounds. Key
applications for the Evapeos are active pharmaceutical ingredient and
natural product concentration.
The Evapeos utilizes a process called osmotic distillation to rapidly
remove water from critical samples. This process involves the transfer
of water (as a vapour) from a diluted aqueous medium toward an aqueous
osmotic agent. These two miscible fluids are separated by a gas
permeable, hydrophobic hollow fibre with high porosity. The difference
in water activities between the two compartments leads to a high water
vapour flux even at room temperature and at atmospheric pressure.
Evapeos evaporators are controlled through intuitive colour touch screens and use cartridges that contain thousands of hollow fibres to generate high water fluxes of up to 1 L per hour at 40°C. The unit does not require a vacuum and a range of different-sized
FDA-approved cartridges are available to allow samples to be
concentrated down from a sample size of up to 1 L to as low as 25 mL.
Separate cartridges can be used for different products in order to avoid
cross-contamination.
Accessories
EvapeosG
This highly hygroscopic liquid osmotic agent is used in the Evapeos to absorb water from the sample being concentrated. EvapeosG is a patent pending food-grade product manufactured by Ederna for optimal performance of the Evapeos. It can be disposed of after use or reused after being regenerated. This product is available in 5 L cans.
Cartridges
The Evapeos uses cartridges that contain several thousand gas permeable hollow fibers in order to generate high water fluxes out of a sample. The cartridges are easily exchangeable so that they can be dedicated to a product or a batch in order to prevent cross-contamination. These cartridges are FDA-approved and several sizes are available depending upon the volume of sample to be concentrated.
Sensors
Once connected to the Evapeos these disposable sensors provide continuous monitoring of sample temperature and pressure.
Tubing
The tubing used in the Evapeos is made of superior flex memory platinum-cured silicon that doubles the accuracy of dispensed volumes when compared to standard platinum-cured silicon tubing. The tubing is fully post-cured and developed for biopharmaceutical applications. The ultra-smooth bore quality of the tubing helps to minimize protein binding and ensure high purity levels in the finished product. The tubing is easily exchanged and meets FDA requirements.
Thermostats
These thermostats allow the temperature of the sample to be precisely controlled during concentration.
More Information
Please click here to view a video of the Evapeos or contact Discovery to obtain pricing for the Evapeos and available accessories.
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