Microplate filler, deep well microplate filling, aspirate and dispense systems, automated liquid dispensing, cell printing, nanofabrication

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Microplate aspirate and dispense system (A500)

Key Features:

Highly accurate non-contact dispensing into 96- and 384-well standard height or deep well plates.
Up to 16 different dispense channels each with its own fluid pathway
Open construction and RS232 port for easy integration with robotic systems
Up to 25 user programmable wash protocols
Optical liquid level sensing in all reservoirs with visual warning system
Extremely easy to clean and maintain
Remote control PC software available

The A500 microplate aspirate and dispense system is a novel instrument for the fully automated filling and aspirating of 96- and 384-well microplates. It can also be used with deep well plates. The A500 has been designed to achieve fast and reliable microplate processing with high precision and repeatability and at the same time providing the user with considerable flexibility for protocol design.

Specifications

Dispense reservoir	3 x 2 L
Waste reservoir	2 L
Precision	± 3% at 300 µL
Residual volume	3 µL per well or 1 µL per well with sweep function
Dispensing volume range and increments	5uL – 100ul: increments of 2.5 uL 10ul – 200ul: increments of 5.0 uL 12.5ul – 500ul: increments of 12.5uL
Weight	6 Kg
Dimensions	65 cm x 65 cm x 35 cm (WxDxH)

Ordering Information

Part No.	Description
L093-8	8-channel filler
L093-16	16-channel filler (96 and 384 well plates)

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	CellJet cell printing system Key Features Printed cell viability >95%. ± 10 um spatial accuracy and a volume range 700pL - 4uL 1536-well plate filled in <1 minute Systems can be configured for a wide range of applications: One channel for simple cell printing, 2-channel for multiple cell types or cell and reagent printing, and 4-channel for bulk dispensing of cells. Larger plate and deck formats are available to support both research and high throughput robotic integration. Multiple channels can be used for multiple cell lines. The CellJet supports multiplex assays without cross- contamination. Full control of dispense height and dispensing speed offers easy optimization, improved performance and faster results for a wide variety of cell types. Choice of drop-by-drop or on-the-fly dispensing modes for optimized performance and increased throughput. System dispenses a full range of cell types from robust to delicate. synQUAD technology is able to dispense fluid types from low viscosity solvent to highly viscous solutions such as 30% PEG. Ideal for protein/DNA suspensions or hydrogels. The CellJet includes a cover over each plate which creates a micro-environment for each cell to prevent contamination and evaporation. The cover is removable for easy cleaning and sterilization. The CellJet can fit into most standard fume hoods or can be purchased with an enclosed chamber with optional humidity control. Flexible, easy-to-use software offers productivity to multiple users with minimal training. The CellJet Cell Printer incorporates Digilab’s proprietary synQUAD liquid dispensing technology that offers both on-the-fly and drop-by-drop non-contact cell printing while maintaining the viability of even the most delicate cells. This extremely flexible technology offers users full control over critical dispense parameters such as height of dispense and dispensing speed which allows printing of both viscous solutions and fragile cells. The CellJet prints into plates or onto slides using a valve-free fluid path which greatly reduces cell damage. The printer also includes full wash capability, an easy-to-clean and sterilize evaporation cover and an effective instrument design for hassle-free maintenance. Applications Stem cell research Cell sorting core facilities/FACS centers Live cell deposition and printing Stem cell cloning and manipulation Live cell arrays Live cell layering with or without matrixes Live cell assays Cell migration assays – Pharma scratch tests Cell differentiation assays Tissue construction in vitro Tissue engineering & scaffold construction More Information Please click here to download a PDF brochure on the Digilab CellJet or watch a video of the CellJet in action. Learn more about synQUAD technology and its applications. Download a list of accessories for the Celljet. *Application Notes* Application of CellJet technology for precise "printing" of adherent mammalian cells with no loss of viability Application of CellJet technology for precise "printing" of mammalian cell lines grown in suspension Precise Dispensing with no Loss in Viability - Human Muscle Stem Cell Smooth Muscle Cells: Use of CellJet Technology for Precise Dispensing with no Loss in Viability Bioprinting Human Mesenchymal Stem Cells Using the Celljet Bioprinting Human Mesenchymal Stem Cells Suspended in Alginate in Patterns Using the CellJet Without Loss in Cell Viability

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	GIX Microplotter II compact precision picoliter printer Key Features: Non-contact deposition Features as small as 5 μm Viscosities up to 450 cP True contiguous lines, arcs, and bends Microstructure fabrication Consistent spot size and shape with coefficients of variability as low as 10% 3-axis positioning with 5 μm resolution Integrated digital video capture Automated surface calibration The SonoPlot^® GIX Microplotter II is a precision picoliter fluid dispensing system for the life science microarray, polymer, electronics and nanotechnology/nanofabrication markets with significant advantages over existing products in deposited feature size and type, regularity of volumes dispensed, and flexibility for the user. Key applications include: Rapid prototyping Graphene/ carbon nanotube printing Additive repair Polymer microstructure fabrication pOLED printing High-density protein microarrays Patterning of live cells The GIX Microplotter II utilizes the same innovative technologies as the Microplotter Desktop and the Microplotter to deposit fluid in a non-contact manner to form single droplets or contiguous lines, arcs or bends. These are uniform elements and are not constructed from overlapping droplets like other technologies. This makes the Microplotters particularly well-suited to the polymer electronics field. The Microplotter II offers consistent spot size and shape with coefficients of variability as low as 10% and 3-axis positioning with 5 μm resolution. Custom enclosures are available for the GIX microplotters. Features include HEPA filtration (Class 100), humidity control and UV sterilization. More Information Please click here to view a Microplotter printing video. Download a brochure describing the GIX Microplotter II. *Sample Printing* Need to determine if a GIX microplotter is right for your application? Then just send us your samples (and your DXF files if you have them) and we'll run a *free* sample plot for you. Contact Discovery Customer Service for details. Application Notes Deposition of catalyst for carbon nanotube growth Drawing a polymer-based blue LED Mass spectrometry enhancement through small spots Printing lines of nanometallic ink for conductive electronic traces Spotting DNA at a high resolution for microarray fabrication Spotting proteins for an ELISA-type microarray assay

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	GIX Microplotter Desktop picoliter printer Key Features Non-contact deposition Features as small as 5 μm Viscosities up to 450 cP True contiguous lines, arcs and bends Microfeature printing Consistent spot size and shape with coefficients of variability as low as 10% 3-axis positioning with 20 μm resolution Integrated digital video capture The SonoPlot^® GIX Microplotter Desktop is a benchtop picoliter fluid dispensing system for the life science, polymer, electronics and nanotechnology/nanofabrication markets with significant advantages over existing products in deposited feature size and type, regularity of volumes dispensed, and flexibility for the end-user. Key applications include: Rapid prototyping Macro-electronics printing Protein microarrays Patterning of live cells. The core of the Microplotter Desktop is a dispenser that uses controlled ultrasonics to deposit fluids in a non-contact manner. This patented technology can produce picoliter droplets that form features on a surface as small as 5 μm wide. When combined with automatic surface height calibration, coefficients of variability for deposited feature diameters as small as 10% can be achieved. A wide range of fluids can be used, including aqueous solutions and many organic-solvent-based mixtures. Fluids that other dispensers struggle with, such as saturated solutions for MALDI-TOF matrices, or fluids with viscosities up to 450 cP, can be deposited with ease. The ultrasonic pumping action is also an efficient cleaning mechanism for quickly depositing many solutions sequentially. Custom enclosures are available for the GIX microplotters. Features include HEPA filtration (Class 100), humidity control and UV sterilization. More Information Please click here to view a Microplotter printing video. Download a brochure describing the GIX Microplotter Desktop. *Sample Printing* Need to determine if a GIX microplotter is right for your application? Then just send us your samples (and your DXF files if you have them) and we'll run a free sample plot for you. Contact Discovery Customer Service for details. Application Notes Deposition of catalyst for carbon nanotube growth Drawing a polymer-based blue LED Mass spectrometry enhancement through small spots Printing lines of nanometallic ink for conductive electronic traces Spotting DNA at a high resolution for microarray fabrication Spotting proteins for an ELISA-type microarray assay

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	synQUAD non contact aspirate and dispense systems The synQUAD dispensing platforms are ideal for the bulk addition of reagents to assay plates containing compounds for investigation. Use synQUAD to add buffers, receptors, enzymes and cells. SynQUAD systems also provide aspirate and dispense capability. This is useful for transferring limited volume samples such as live cells, enzymes, reagents or proteins. The proprietary synQUAD technology was developed for high-speed dispensing. The technology involves the coupling of a high-speed micro-solenoid valve with a high resolution syringe pump and synchronization of the dispense system with the translation stage. The result is an extremely fast dispensing system which can deliver volumes from 20 nL to 20 µL. The synQUAD dispensing systems are able to place 500 nL into 1536 wells in 20 seconds. This revolutionary non-contact dispensing of drops on the fly is ideal for the most demanding HTS dispensing applications where high-speed and precise low volumes are required. The synQUAD technology is available in a number of configurations. Please download the synQUAD Technology brochure for a complete list of options. A technical bulletin (102) describing the theory and applications of synQUAD technology is available for download and a video showing synQUAD non-contact systems in operation can also be viewed. Technical Note 103 is also available for researchers looking for a method to automate and miniaturize SNP genotyping assays. More Information Please click here to download synQUAD Technology brochure Download Technical Bulletin 102 on synQUAD theory and applications View video of synQUAD non-contact systems in operation Download Technical Note 103 on SNP genotyping assay automation and miniaturization

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	MicroSys high-throughput aspirate and dispense system Key Features: 4 synQUAD™ channels 3 microplate positions or 11 slides Integrated wash/vacuum system Vacuum pump Computer controller and software The MicroSys high-throughput aspirate & dispense system utilizes proprietary non-contact synQUAD™ technology and can be used to automate TaqMan SNP genotyping assays in 384 well plate formats. Consequently it has become an essential tool for large scale genotyping projects. The MicroSys helps to minimize routine bench work and automate the initial extensive volume reduction gradient to determine if reactions can be performed at lower volumes. This is important since not all TaqMan SNP genotyping assays are the same and there is considerable variation in sensitivity between different assays. Large-scale genotyping can commence once an optimum reduced reaction volume has been determined. The MicroSys can be configured with either a three microplate nest or an 11 slide nest and can dynamically dispense volumes from 20nL to 20uL. Materials providing specifications for the MicroSys and its use for specific applications can be downloaded below. Additional Information on the principles behind synQUAD technology and its applications can be downloaded by clicking on the links above in the Aspirate & Dispense Systems section. More Information Download more details and specifications on the MicroSys systems Download Application Note 1201 on volume reduction strategies for TaqMan SNP genotyping assays using the MicroSys Download Application Note 1200 on volume reduction strategies for high-throughput capillary sequencing using the MicroSys

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	PixSys high-speed aspirate and dispense system Key Features: 8 synQUAD™ channels Choice of 10 microplate positions or 50 slide positions Integrated wash/vacuum system Vacuum pump Computer controller and software The PixSys is a high speed dispensing system with the option of a 10 microplate or 50 slide nest configuration. The synQUAD™ pumps incorporated into the PixSys provide multiple methods for liquid dispensing that includes: Discrete drops (20 nL- several mLs). Individual drops are useful for applying small drops onto a solid target substrate or into a well. Burst of drops (e.g. 1.0 µl dispensed in 100nl drops). This method improves mixing when dispensing into filled wells of a plate and reduces splashing if a large volume is dispensed into the filled wells of a plate. Fast stream (dispensing of large volumes up to full syringe volume). This method is ideal for applications where filling a target well with a large volume of sample or diluent is required. Line of drops (control of drop size and spacing). Line mode allows for rapid dispensing onto target. Materials providing specifications for the PixSys and its use for specific applications can be downloaded below. Additional Information on the principles behind synQUAD technology and its applications can be downloaded by clicking on the links above in the Aspirate & Dispense Systems section. More Information Please download more details and specifications on the PixSys systems

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	PreSys small footprint aspirate and dispense system Key Features: 8 synQUAD™ Channels 2 Microtiter Plate Positions: 1 Active for Robot Interface 1 Passive Integrated Wash/Vacuum System Vacuum Pump Computer Controller Optional Plate Handler The PreSys is a small footprint workstation with a 2 microplate configuration. It uses proprietary synQUAD™ Technology and is designed for the automation friendly laboratory. The synQUAD™ dispensers enable the researcher to select the motion of the dispenser. When high speed is a the priority drops can be dispensed on-the-fly and a single channel can fill a 1536 well plate in less than two minutes. On-the-fly dispensing is achieved by synchronizing not only the syringe and valve but also the movement of the platform. Some applications do not require the highest speed but do require good positional accuracy. The stop-and-drop dispense mode of the PreSys is ideal for these applications. It can place the dispense tip down to less than a mm above the destination and positioning the drop with exceptional accuracy. Materials providing specifications for the PreSys and its use for specific applications can be downloaded below. Additional Information on the principles behind synQUAD technology and its applications can be downloaded by clicking on the links above in the Aspirate & Dispense Systems section. More Information Please download more details and specifications on the PreSys systems

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